Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

In most liberal democracies for example, the central bank is as independent as the supreme court, yet deals with a wide range of economic, social, and political issues. How do these public servants make these policy decisions? What normative principles inform their judgments? In The Machinery of Government, Joseph Heath attempts to answer these questions. He looks to the actual practice of public administration to see how normative questions are addressed. More broadly, he attempts to provide the outlines of (...) a "philosophy of the executive" by taking seriously the claim to political authority of the most neglected of the three branches of the state. (shrink)

If ever I summon before me my highest ideals of men and medicine, I find them sprung from the spirit of Osler. —Wilder Penfield, M.D. Neuroethics is a recently coined term that is shaping our cultu...

In our papers on the rationality of magic, we distinghuished, for purposes of analysis, three levels of rationality. First and lowest (rationalitYl) the goal directed action of an agent with given aims and circumstances, where among his circumstances we included his knowledge and opinions. On this level the magician's treatment of illness by incantation is as rational as any traditional doctor's blood-letting or any modern one's use of anti-biotics. At the second level (rationalitY2) we add the element of rational thinking (...) or thinking which obeys some set of explicit rules, a level which is not found in magic in general, though it is sometimes given to specific details of magical thinking within the magical thought-system. It was the late Sir Edward E. Evans-Pritchard who observed that when considering magic in detail the magician may be as consistent or critical as anyone else; but when considering magic in general, or any system of thought in general, the magician could not be critical or even comprehend the criticism. Evans-Pritchard went even further: he was sceptical as to whether it could be done in a truly consistent manner: one cannot be critical of one's own system, he thought. On this level (rationalitY2) of discussion we have explained (earlier) why we prefer to wed Evans Pritchard's view of the magician's capacity for piece-meal rationality to Sir James Frazer's view that magic in general is pseudo-rational because it lacks standards of rational thinking. (shrink)

In Albert M. Hyamson’s invaluable reference work “The British Consulate in Jerusalem in relation to the Jews in Palestine 1838–1914” a letter from Sir Moses Montefiore is quoted. Montefiore was at that time President of the London committee of Deputies of the British Jews. The letter is addressed to Earl Russell, the Foreign Secretary, and in this letter Montefiore mentions that he is enclosing a Memorial from the Jewish Communities in Safed and Tiberias, complaining about the deplorable condition in which (...) they find themselves as a consequence of the withdrawal of British Protection which they had enjoyed during the preceding 10 years. The original Memorial is an address to Sir Moses Montefiore, sent by the Ashkenazi Chief Rabbis of Safed and Tiberias in 1863. (shrink)

ABSTRACT The main cause of the crisis was the behavior of the banks—largely a result of misguided incentives unrestrained by good regulation. Conservative ideology, along with unrealistic economic models of perfect information, perfect competition, and perfect markets, fostered lax regulation, and campaign contributions helped the political process along. The banks misjudged risk, wildly overleveraged, and paid their executives handsomely for being short‐sighted; lax regulation let them get away with it—putting at risk the entire economy. The mortgage brokers neglected (...) due diligence, since they would not bear the risk of default once their mortgages had been securitized and sold to others. Others can be blamed: the ratings agencies that judged subprime securities as investment grade; the Fed, which contributed low interest rates; the Bush administration, whose Iraq war and tax cuts for the rich made low interest rates necessary. But low interest rates can be a boon; it was the financial institutions that turned them into a bust. (shrink)

JOSEPH AGASSI 1. Sir Karl Popper has offered two different theories of scientific progress, his theory of conjectures and refutations and corroboration, as well as his theory of verisimilitude increase. The former was attacked by some old-fashioned inductivists, yet is triumphant; the latter has been refuted by Tichy and by Miller to Popper’s own satisfaction. Oddly, however, the theory of verisimilitude was developed because of some deficiency in the theory of corroboration, and though in its present precise formulation it (...) was refuted, Popper still holds it in general terms, and I think he still hopes to find a better precise formulation of it. My aims in the present note are to pin-point the deficiency of Popper’s theory of corroboration and to use this for a precise formulation of verisimilitude increase acceptable to him. For my part, however, I see the situation in a different way, as will be indicated at the end of this note. (shrink)

While neuroethics is generally thought to be a modern addition to the broader field of bioethics, this subdiscipline has existed in clinical practice throughout the course of the 20th century. In this essay, Fins describes an older tradition of clinical neuroethics that featured such physician-humanists as Sir William Osler, Wilder Penfield, and Fred Plum, whose work and legacy exploring disorders of consciousness is highlighted. Their normative work was clinically grounded and focused on the needs of patients, in contrast to modern (...) neuroethics, which is more speculative and distant from the lived reality of the clinic. Using recent developments in the diagnosis and treatment of disorders of consciousness, and the history of the vegetative and minimally conscious states, Fins asks why modern neuroethics has taken this turn and what can be done to restore clinical neuroethics to a more proportionate place in the field. (shrink)

Patriotism is a form of loyalty. The range of loyalty is from patriotism to friendship. Liberals were often accused of having no sense of loyalty. They usually tend to deny the charge — even while refusing to take a loyalty oath. Even the liberal philosopher Sir Karl Popper has claimed (Open Society, i, ch. 10), that liberals can be better patriots than others. 1 find this line of defense erroneous and morally wrong. I find it much nicer, much more honest, (...) to join Martin Buber in his taking Jeremiah as a model because when he felt that capitulation to the enemy is morally justified he recommended just that. Buber, fearful of the effects of patriotism, opposed the foundation of a Jewish state and proposed, instead, a program.. (shrink)

Purpose: This paper aims at exposing and appraising the arguments of A.J. Ayer against metaphysics, as reflected in the first chapter of his book, Language, Truth and Logic. It shall explore the basic assumptions, content and concerns of the metaphysical enterprise, and place them in careful juxtaposition with A.J. Ayer’s positivist assumptions in order to discover whether the claims he makes regarding metaphysics are really valid or not. The conclusion will emphasize the relevance and irrefutability of metaphysics. Methodology: The work (...) is expository, analytic, critical and evaluative, in its methodology. Findings: Sir Alfred Julius Ayer was an English philosopher who developed key features of logical positivism. His book Language, Truth, and Logic (1936) is one of the most influential philosophy books in the 20th century, addressing questions of reality, perception, knowledge and meaning. In it Ayer explains important positivist ideas, like the principle of verifiability as a criterion of meaning, the rejection of metaphysics, and the emotivist theory of ethics. In Ayer’s logical empiricism, philosophy is no longer seen as a metaphysical concern, nor as an attempt to provide speculative truths about the nature of ultimate reality. Instead, philosophy is seen as an activity of defining and clarifying the logical relationships of empirical propositions. Unique Contribution to theory, practice and policy (recommendation): The ratiocinative discussion of A. J. Ayer’s rejection of Metaphysics, offers an alternative perspective on how Metaphysics should be construed, given its centrality to, and in-eliminability in philosophical discourses. (shrink)

I. Scientific method as a mental operation [by] T. Case.--II. On some aspects of the scientific method [by] F. Gotch.--III. Physiology; its scope and method [by] C. S. Sherrington.--IV. Inheritance in animals and plants [by] W. F. R. Weldon.--V. Psycho-physical method [by] W. McDougall.--VI. The evolution of double stars [by] A. H. Fison.--VII. Anthropology: the evolution of currency and coinage [by] Sir R. C. Temple.--VIII. Archaeological evidence [by] W. M. F. Petrie.--IX. Scientific method as applied to history [by] T. B. (...) Strong. (shrink)

The studies of theoretical bias in evidence are these days developed by many clever psychologists, social psychologists, and philosophers. It therefore comes as a surprise to realize that most of the material one can find in the up-to -date literature repeats discoveries which are due to the heroes of the present sketch, namely Galileo Galilei, Sir Francis Bacon, and Robert Boyle; William Whewell, Pierre Duhem, and Karl Popper. We may try to raise scholarly standards by familiarizing ourselves with their ideas (...) and studying them with a little appreciation. (shrink)

It may be objected that musical analysts claim to be working with objective methodologies which leave no place for aesthetic criteria, for the consideration of value. If that were the case, the reluctance of so many writers to subsume analysis under criticism might be understandable. But are these claims true? Are they, indeed, even seriously entered?Certainly the original masters of analysis left no doubt that for them analysis was an essential adjunct to a fully articulated aesthetic value system. Heinrich Schenker (...) always insisted on the superiority of the towering products of the German musical genius. Sir Donald Tovey pontificated about "the main stream of music" and on occasion developed this metaphor in considerable detail. It is only in more recent times that analysts have avoided value judgments and adapted their work to a format of strictly corrigible propositions, mathematical equations, set-theory formulations, and the like—all this, apparently, in an effort to achieve the objective status and hence the authority of scientific inquiry. Articles on music composed after 1950, in particular, appear sometimes to mimic scientific papers in the way that South American bugs and flies will mimic the dreaded carpenter wasp. In a somewhat different adaptation, the distinguished analyst Allen Forte wrote an entire small book, The Compositional Matrix, from which all affective or valuational terms are meticulously excluded. The same tendency is evident in much recent periodical literature.Joseph Kerman, professor of music at the University of California at Berkeley, has been the editor of Nineteenth-Century Music. His books include Opera as Drama, The Elizabethan Madrigal, The Beethoven Quartets, Listen , and The Masses and Motets of William Byrd. (shrink)

Are there qualities of sound and the experience of listening that educators can extrapolate to inform the philosophy and practice of music education? In this essay, I imagine a music education where sound—how it behaves and how we experience it—serves not only as the subject of study, but generates the framework of the pedagogy. A sonic music education is not automatic because ocularcentrism privileges the vision and influences the listening and educational experiences, often in unrecognized ways. I explore two qualities (...) of sounds: they are, first, impermanent and continually changing and, second, diffuse—seemingly inside and outside our bodies. These qualities contrast with the visual experience, which makes objects appear permanent, fixed, and separate from our bodies. Pedagogies based on sound might present truth as impermanent and their aims as multidirectional and might employ social constructivist epistemologies and democratic education. A music education based on sounds may be a corrective to ocularcentric banking pedagogies where knowledge is fixed and progress is unidirectionally measured. (shrink)

Woods is an insightful and thoughtful authority on the Bretton Woods institutions. In this book she examines their activities and focuses on their engagements with Mexico, Russia, and the sub-Saharan African nations.

The idea of verisimilitude is implicit in the writings of Albert Einstein ever since 1905, when he declared the distribution of field energy according to Maxwell's theory an approximation to that according to quantum-radiation theory, and Newtonian kinetic energy an approximation to his relativistic mass-energy. All his life Einstein presented new ideas as yielding older established ones as special cases and first approximations. The news has reached the philosophical community via the writings of Sir Karl Popper half-a-century after Einstein's trailblazing (...) conception — first in his epoch-making "Note on Berkeley as a Precursor to Mach" and then in his classic "Three Views Concerning Human Knowledge". (shrink)

The variety of languages in the world is considered a curse by some, who view the phenomenon as a Tower of Babel. Others consider it the most characteristic quality of human language as opposed to animal languages, which are supposedly species specific. The variety is viewed as a symptom of human caprice, arbitrariness, or dependence on mere historical accident by some; and as a symptom of human freedom and of the creative aspect of language by others. And, of course, the (...) human limitation caused by the variety of languages and the peculiarities of traditions within languages, as instanced by Sir Winston Churchill's The History of the English Speaking People, are again viewed by different thinkers from different philosophical viewpoints. (shrink)

Karl Popper's methodology can be seen as the situational logic of research. Popper called his method "Epistemology without a Knowing Subject." It was dismissed as metaphysical by those who refuse to give up an ideal knowing subject (a perfect human inductive processor). This article surveys the failure of modem discussions of this ideal, from the earliest (the writings of Sir Francis Bacon) to the latest (Kripke). The knowing subject exits at last, but leaves behind interesting results. The ideal knowing subject (...) embodied ideal rationality, outside culture and history. Giving up this ideal invites us to integrate science with its background, to grade rationality (from magic to science), and to integrate different degrees of rationality under one rule. (shrink)

is an unusual phenomenon. The concern with rights different citizens have in different societies is legal rather than philosophical. It is frequently somewhat a technical matter for jurisprudence to decide exactly what rights a citizen has in a given situation and how he might best exercise his rights. Often, to be sure, the legal technicalities involve matters of principle, and if so these should be made explicit. For this, too, there is a need less for philosophy and more for jurisprudence, (...) for detailed legal study. For example, the problems concerning interests of third parties - related to the questions of when is a third party an aggrieved person, so-called, and what are the rights of the aggrieved third party - have been taken up, in the sixties, by diverse federal courts of the United States, with the aim of increasing individual rights when these are encroached upon by public agencies.1 Although this may call for much philosophical commentary, it is clearly more a legal matter than a philosophical concern. Even the broadly philosophical question of rights within a legal system requires a greater degree of legal than philosophical considerations. Recently H.L.A. Hart, the foremost living legal philosopher, has cited Sir Henry Maine (1891) and William Warwick Buckland (1950) approvingly to support his view that even "Roman law never achieved a clear concept of a legal right." 2 It is not clear to a philosopher what "a clear concept of legal rights" might be, and a philosopher like Hannah Arendt never. concerned herself with this matter when she expressed her admiration for the rights of a Roman citizen to his privacy.3 Regardless of whether we admire or deplore this, we can agree that at least in principle a Roman citizen had more rights and prerogatives within his family than any modern civilized law would ever permit. A philosopher with only a modicum of sensitivity can say that although Rome was not a democracy, and even though in Rome the rights of women and children (not to mention slaves) were not recognized, the rights of citizens to privacy and to be free of the need ever to prove their innocence have nevertheless become the foundation stones of modern liberal individualistic democracy.. (shrink)

Written and set on the banks of the Neva, St Petersburg Dialogues is a startlingly relevant analysis of the human prospect at the end of the twentieth century. As the literary critic George Steiner has remarked, "the age of the Gulag and of Auschwitz, of famine and ubiquitous torture,... nuclear threat, the ecological laying waste of our planet, the leap of endemic, possibly pandemic, illness out of the very matrix of libertarian progress" is exactly what Maistre foretold. In the (...) Dialogues Maistre addressed a number of topics which are discussed briefly or not at all in his other works already available in English. These include an apologetic for traditional Christian beliefs about providence, reflections on the social role of the public executioner and the "divinity" of war, a critique of John Locke's sensationalist psychology, meditations on prayer and sacrifice, and a mini-course on "illuminism." The literary form is that of the "philosophical conversation" -- one that allowed Maistre to be deliberately provocative and to indulge his taste for paradox, a "methodical extravagance" that he judged particularly appropriate for the eighteenth-century salon. Translator and editor Richard Lebrun provides a full scholarly edition of this classic work, complete with an introduction, chronology, critical bibliography, and generous explanatory notes. The Dialogues will be of interest to scholars of literary history as well as the history of ideas. (shrink)

In this memorial essay on Sir Frank Kermode (1919–2010), the author focuses on his own exchange of views with Kermode during the 1970s. In Kermode's book The Sense of an Ending (1966), he had criticized Frank's essay “Spatial Form in Modern Literature” (1945) as part of a larger critique of what the Romantic-Symbolist tradition of English poetry had become in the twentieth century. Yeats, Pound, Eliot, and other late Symbolists had turned artists into advocates of an irrational wisdom superior to (...) reason and common sense, thus isolating—so Kermode argued—the world of art from that of ordinary human concerns. Rejecting their view of art, he turned instead to a pre-Romantic tradition (including Spenser and Milton) that the Symbolists had rejected. Among modern writers, Kermode turned to Wallace Stevens, who became his foil for Yeats, Eliot, and Pound, as well as the most important influence on his own later thinking. Joseph Frank, in this essay, recalls the combination of acerbic intelligence, social concern, gentility, and finally friendship that characterized his debate over these questions with Kermode. Frank recalls as an indication of his respect and admiration for Kermode that he wrote, in 1977, that, even if his own theory of spatial form were to be shown worthless, it would still have value in having provided some of the stimulus for Kermode to write The Sense of an Ending. (shrink)

ABSTRACT:U.S. Organizational Sentencing Guidelines provide firms with incentives to develop formal ethics programs to promote ethical organizational cultures and thereby decrease corporate offenses. Yet critics argue such programs are cosmetic. Here we studied bank employees before and after the introduction of formal ethics training—an important component of formal ethics programs—to examine the effects of training on ethical organizational culture. Two years after a single training session, we find sustained, positive effects on indicators of an ethical organizational culture (observed unethical behavior, (...) intentions to behave ethically, perceptions of organizational efficacy in managing ethics, and the firm’s normative structure). While espoused organizational values also rose in importance post-training, the boost dissipated after the second year which suggests perceptions of values are not driving sustained behavioral improvements. This finding conflicts with past theory which asserts that enduring behavioral improvements arise from the inculcation of organizational values. Implications for future research are discussed. (shrink)

ABSTRACT:U.S. Organizational Sentencing Guidelines provide firms with incentives to develop formal ethics programs to promote ethical organizational cultures and thereby decrease corporate offenses. Yet critics argue such programs are cosmetic. Here we studied bank employees before and after the introduction of formal ethics training—an important component of formal ethics programs—to examine the effects of training on ethical organizational culture. Two years after a single training session, we find sustained, positive effects on indicators of an ethical organizational culture (observed unethical behavior, (...) intentions to behave ethically, perceptions of organizational efficacy in managing ethics, and the firm’s normative structure). While espoused organizational values also rose in importance post-training, the boost dissipated after the second year which suggests perceptions of values are not driving sustained behavioral improvements. This finding conflicts with past theory which asserts that enduring behavioral improvements arise from the inculcation of organizational values. Implications for future research are discussed. (shrink)

Those accustomed to viewing John Locke as the benign forefather of American Liberalism will be shocked by this book, for Locke was neither benign nor liberal nor even tolerant when it came to serious things in life like money, economic policy, and the Bank of England. In this careful and exhaustive study of Locke's philosophy of money, Caffentzis details the ways in which Locke sought to replace the concept of God, State, Law, and other ultimates with a much more empirically (...) reliable "substance"--money. Locke, it seems, was quite willing to allow any amount of exotica to pass for religion, but his tolerance gave out when it came to the coin of realm. (shrink)

Does the level of marketing activity in a country contribute to societal well-being or quality of life? Does economic efficiency also play a positive role in societal well-being? Does economic efficiency also moderate or mediate the marketing activity effect on societal well-being? Marketing activity refers to the pervasiveness of promotion expenditures and number of retail outlets per capita in a country. Economic efficiency refers to the extent to which the economy is unhampered by corruption, burdensome government regulation, and a large (...) informal economy. We used secondary data from the World Bank and other statistical sources to answer these questions. Our study findings suggest that both marketing activity and economic efficiency contribute positively to societal well-being, and that economic efficiency plays more of a mediator than moderator role between marketing activity and societal well-being. The public policy implication of this study is that increases in marketing activity and economic efficiency in countries characterized as low on both dimensions should significantly increase the quality of life in those countries. (shrink)

We suggest that policies will be less popular when individuals personally have to pay for them rather than when others have to pay (i.e., a Not Out of My Bank Account or NOMBA effect). Dual process models of persuasion suggest that personally having to pay would motivate scrutiny of persuasive messages making it essential to use effective science communication tactics when using climate science to support climate change policies. A pilot experiment (N = 186) and main study (N = 758) (...) support a NOMBA effect with less policy support (Pilot study) and lower recommended fees (Main study) for a policy that would require participants, rather than another group, to pay a fee for community solar panels. Consistent with dual process models and suggesting systematic processing, only when participants would have to pay the fee, messages using strong (vs. weak) science communication tactics increased support for policies (Pilot study), increased the favorability of thoughts about the policy (Main study) and these thoughts subsequently predicted policy support (Main study). Inconsistent with propositions that information about expert sources would be a heuristic or bolster science messages, expert consensus information did not influence thoughts or policy support in any study condition. Efforts to understand climate change policy support would benefit from attending to research on dual process models of persuasion, including understanding how different types and degree of outcome relevance can alter how people process science information used to bolster support for climate change policies. (shrink)